I've read lots of commentary on the suicide of Aaron Swartz, but a post from Brad Feld resonated with me the most: "The Importance Of A Monthly Cadence With Close Friends". it is a quality read for anybody running their business from home.
I've been working from home since 2004, and while I prefer the enviroment to focus, it can get a little isolating.
So, back in 2010, as I was moving to Austin, TX without really knowing anybody, I went to meetup.com and joined a bunch of relevant groups. It was such a helpful move to make lots of connections quickly, and I've become close through there with a number of people who were strangers not so long ago.
And I really enjoy those lunches with local friends on multiple levels.